[13] The evidence linking benzophenone and different derivatives to endocrine disruption is complex, and research suggests that different benzophenones have different endocrine effects. [1] [2] These chemicals are linked to cancer, endocrine disruption, and organ system toxicity. [28] [36] Oxybenzone is persistent and can collect in fat. [33] Other studies suggest that use can lead photoallergy, allergic contact dermatitis and facial erythema. It can contaminate drinking water and migrate from food packaging into food. List the CAS number and hazards associated with benzophenone, C_13 H_18 O. 2. a) molality: Molality is defined as numbe view the full answer [18] The European Commission on Endocrine Disruption has determined that there is not yet sufficient evidence that benzophenone itself is a human endocrine disruptor. [38], VULNERABLE POPULATIONS: Women and infants, REGULATIONS: Benzophenone, benzophenone-2, benzophenone-3, benzophenone-4, and benzophenone-5 restricted in cosmetics in United States[3] and oxybenzone is restricted in cosmetics at up to 10% maximum concentration in the EU.[4]. Ecotoxicity: Benzophenone is toxic to aquatic organisms. [30], [31] Benzophenone | C6H5COC6H5 or C13H10O | CID 3102 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Organ System Toxicity: The European Food Safety Authority (EFSA) classifies benzophenone as a known toxicant because benzophenone can cause liver hypertrophy in the rat at lower doses. [18] The European Commission on Endocrine Disruption has determined that there is not yet sufficient evidence that benzophenone itself is a human endocrine disruptor. Safety Measures/Side Effects of Benzophenone-3: There are several suspected dangers associated with benzophenone … Some studies indicate that benzophenone has little estrogenic activity. [33] Other studies suggest that use can lead photoallergy, allergic contact dermatitis and facial erythema. This chemical absorbs through the skin in significant amounts. Show transcribed image text. 119-61-9] Generic name: Benzophenone Synonyms: Diphenylmethanone, Diphenyl ketone, Benzoylbenzene, BZP … [12] Experimental studies suggest benzophenone may lead to several kinds of tumors. Benzophenone is used in personal care products such as lip balm and nail polish to protect the products from UV light. BP2 affects ovaries of female fish and testes of male fish, and also reduces production of eggs and sperm. [16] However, studies of benzophenone in juvenile female rats conclude that benzophenone s not estrogenic itself, but may become estrogenic when it is metabolized by the body into other chemicals (for instance, the benzophenone metabolite p-hydrosybenzophenone is estrogenic). In most cases, concentrations present low hazards to aquatic systems. Benzophenone 59 Hazard assessment of benzophenone [Benzophenone, CAS No. Derivatives of benzophenone, such as benzophenone-2 (BP2) and oxybenzone (benzophenone-3 or BP3) are common ingredients in sunscreen. What is the lowest possible melting point for ice that could be obtained considering the solubility of NaCl in water? [16] However, studies of benzophenone in juvenile female rats conclude that benzophenone s not estrogenic itself, but may become estrogenic when it is metabolized by the body into other chemicals (for instance, the benzophenone metabolite p-hydrosybenzophenone is estrogenic). Each notification may be associated with multiple companies. Each notification may be associated with multiple companies. of benzophenone = 119-61-9 Potential hazards associated with benzophenone are irritant when comes in contact with skin, eyes or upon inhalation. [9] Benzophenone and oxybenzone are also used in nail polish, and lip balm. 2. [34] The Cosmetic Ingredient Review does not consider benzophenones used in cosmetics and personal care products to be an irritant. Salt, NaCl, has a solubility of 35.7 g per 100 g of water at 0 °C. FOUND IN: Lip balm, nail polish, foundations, baby sunscreens, fragrance, shampoo, conditioner, hair spray, moisturizers, and foundation, WHAT TO LOOK FOR ON THE LABEL: Benzophenone, ingredients containing the word benzophenone (for example benzophenone-2), BP# (for example BP2), oxybenzone, sulisobenzone, sulisobenzone sodium, WHAT IS BENZOPHENONE? Benzophenone is the organic compound with the formula (C 6 H 5) 2 CO, generally abbreviated Ph 2 CO. Benzophenone 4 (BP4) has low levels of estrogenic activity in studies of cells, but this activity did not lead to changes in body weight and length in fish, which is a sensitive measure of estrogen exposure. Question: List The CAS Number And Hazards Associated With Benzophenone, C_13H_10O. [19], Some studies indicate that the benzophenone derivative, oxybenzone, can elicit strong anti-androgenic activities in a human breast carcinoma cell line MDA-kb2. 1. Expert Answer 100% (1 rating) … GHS Hazard Statements: Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. However, in some of the hotspots (for example, San Diego County) concentrations may be high enough to raise concerns. a. molality b. K c.solute 3. May cause eye and skin irritation. 1. See the answer. Irritation: Studies show that sunscreen products formulated with concentrations of up to 6 percent of oxybenzone rarely led to allergic reactions—in fact, only about 7/10,000 people had an allergic reaction in one study. [29] Oxybenzone can permeate across the skin and accumulate in blood, the kidneys and the liver, and may be toxic to liver cells. HARMFUL IF SWALLOWED OR INHALED. [22] Studies of estrogenic activity and reproductive effects of oxybenzone found that oxybenzone can alter reproductive endpoints in fish species. However, in some of the hotspots (for example, San Diego County) concentrations may be high enough to raise concerns. Oxybenzone is a sunscreen ingredient associated with photoallergic reactions. This Fact Sheet is a summary of available information regarding the health hazards … Privacy [24] Although the evidence is mixed with regard to oxybenzone’s capacity to mimic estrogen, it can be converted into other forms that exhibit estrogenic potencies such as BP8 and 2,4,4’-trihydroxy-benzophenone (THB). [12] Experimental studies suggest benzophenone may lead to several kinds of tumors. [26] The solubility of salt in water does not vary appreciably with temperature, NaCl is an electrolyte that is commonly used to melt ice by lowering its melting point. Developmental and reproductive toxicity: Studies have found that exposure to high doses of BP2 may affect reproduction in fish. Biphenyl occurs naturally in coal tar, crude oil, and natural gas. [10] , [11], In personal care products, benzophenone is used as a fragrance enhancer or to prevent products such as soaps from losing scents and colors in the presence of UV light.

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